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Human Cystatin B antibody

CAT: 0112-ACS0820-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ACS0820-050Size:50 µL
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Description
CSTB, also known as Cystatin B is an anti-protease implicated in myoclonus epilepsy, a degenerative disease of the central nervous system. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. This protein is able to from a dimer stabilized by noncovalent forces and is thought to play a role in protecting against the proteases leaking from lysosomes in cells. CSTB is located in the lysosomes and the cytoplasm, but also in the nucleus.
Product Name Alternative
CystatinB, Cystatin B, CSTB, Stefin B, PME, CST6, CystatinB CHROW21, CPI B, CYTB, EPM1, Liver thiol proteinase inhibitor, STFB
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human CSTB (1-98aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
2F1
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-G affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
Cystatin B, ACS0820-10 µg, ACS0820-20 µg, ACS0820-50 µg, ACS0820-100 µg, ACS0820-250 µg, ACS0820-500 µg, ACS0820-1 mg, ACS0820-10, ACS0820-20, ACS0820-50, ACS0820-100, ACS0820-250, ACS0820-500, ACS0820-1
References & Citations
Turk V, et al., (1991) FEBS Lett. 285 (2) :213-9.; ; Jarvinen M, et al., (1988) Acta Histochem. 82 (1) :5-18.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Neuroscience
NCBI Accession Number
NP_000091
Uniprot Accession Number
P04080
WB Description
The cell lysates were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CSTB antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: A549 cell lysate (35ug) ; ; Lane 2.: U87MG cell lysate (40ug)
IF Description
ICC/IF analysis of CSTB in A549 cells. The cell was stained with ACS0820 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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