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Diflapolin

CAT: 0804-HY-128171-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128171-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP) /soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s of 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50=20 nM) [1].
CAS Number
724453-98-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Epoxide Hydrolase; FLAP
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/diflapolin.html
Purity
99.33
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C(OCC3=NC4=CC=CC=C4S3)C=C2C
Molecular Formula
C22H17Cl2N3O2S
Molecular Weight
458.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Garscha U, et al. Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Sci Rep. 2017;7 (1) :9398. Published 2017 Aug 24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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