Products for Research Use Only
RegisterLogin

Razoxane

CAT: 0804-HY-119425-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-119425-02Size:10 mM - 1 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Razoxane (ICRF 159), a EDTA derivative, is an orally active antiangiogenic topoisomerase II inhibitor. Razoxane has antineoplastic, antiangiogenic, and antimetastatic activities. Razoxanecan be used for the research of renal cell carcinoma (RCC), lung cancer and melanoma cancer[1][2].
CAS Number
21416-67-1
Product Name Alternative
ICRF 159
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/razoxane.html
Concentration
10mM
Purity
99.16
Solubility
10 mM in DMSO
Smiles
CC(CN(CC(N1)=O)CC1=O)N(CC(N2)=O)CC2=O
Molecular Formula
C11H16N4O4
Molecular Weight
268.27
Precautions
H315, H319, H335
References & Citations
[1]J P Braybrooke, et al. A phase II study of Razoxane, an antiangiogenic topoisomerase II inhibitor, in renal cell cancer with assessment of potential surrogate markers of angiogenesis. Clin Cancer Res.2000; 6 (12) :4697-704.|[2]F Wingen, et al. Antimetastatic effects of Razoxane in a rat osteosarcoma model. Clin Exp Metastasis.Jan-Mar 1987; 5 (1) :9-16.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II

Chemical Information

Razoxane

Razoxane is a N-alkylpiperazine.

CAS Number21416-67-1
PubChem CID30623
IUPAC Name4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
Molecular FormulaC11H16N4O4
Molecular Weight268.27
XLogP-1.4
Topological Polar Surface Area98.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count19
Formal Charge0
Complexity404
SMILES
CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
InChI
InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)
InChIKey
BMKDZUISNHGIBY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Razoxane
CAS: 21416-67-1
CID: 30623
Formula: C11H16N4O4
MW: 268.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight268.27
XLogP3-1.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass268.11715500
Monoisotopic Mass268.11715500
Topological Polar Surface Area98.8 Ų
Heavy Atom Count19
Formal Charge0
Complexity404
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA4555-5Razoxane
MBS5775777Razoxane, (R)-
T26047-01Razoxane, (R) -
AR-R01274-01(R) -Razoxane (Levrazoxane)
AR-R01269-01Dexrazoxane ((S) -Razoxane)

Popular Products