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Letosteine

CAT: 0804-HY-107355-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107355-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Letosteine is an orally active, potent and safe expectorant. Letosteine has the effect of scavenging reactive oxygen species (ROS) . Letosteine dissolves bronchial mucus and reduces respiratory inflammation symptoms, and restores gas exchanges and natural defense mechanisms in the lung. Letosteine can be used for acute or chronic respiratory diseases (such as bronchopneumopathies) research[1][2][3][4].
CAS Number
53943-88-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/letosteine.html
Purity
99.78
Solubility
DMSO : 11.11 mg/mL (ultrasonic; adjust pH to 12 with 1M NaOH)
Smiles
CCOC(CSCCC1NC(C(O)=O)CS1)=O
Molecular Formula
C10H17NO4S2
Molecular Weight
279.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Jia L. Letosteine. John Wiley & Sons, Ltd, 2014.|[2]Macquet V, et al. A new contribution to the treatment of chronic bronchopneumopathies: letosteine. Lille Med. 1979;24 (9) :735-738.|[3]Zhou Y, et al. Efficacy and safety of letosteine in the treatment of sputum thickening and expectoration difficulty in patients with respiratory diseases: a multicenter, randomized, double-masked, double dummy, positive drug parallel controlled trial. Pharmazie. 2014;69 (11) :842-849.|[4]Gachon F, et al. Disposition and metabolism of letosteine in rats. Drug Metab Dispos. 1988;16 (6) :853-857.|[5]Gressier B, et al. Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups. Comparison with free-SH drugs. Pharm World Sci. 1995 May 26;17 (3) :76-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
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