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BrettPhos

CAT: 1139-1070663-78-3-05Size: 1 KgDry Ice: NoHazardous: No
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CAT#:1139-1070663-78-3-05Size:1 Kg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BrettPhos CAS 1070663-78-3 is a high-performance dialkylbiaryl monophosphine ligand developed for palladium-catalyzed cross-coupling reactions. This white crystalline powder features ultra-high steric hindrance and unique electronic properties from multiple alkoxy and isopropyl substituents on the biphenyl backbone. Compared with conventional phosphine ligands, BrettPhos exhibits excellent air stability, strong catalytic activity and outstanding functional group tolerance. It is specially optimized for challenging C-N, C-O and C-C cross-coupling reactions, especially suitable for coupling with inactive aryl chlorides, and has become one of the most widely used industrial phosphine ligands in pharmaceutical intermediate synthesis.
Synonyms
2- (Dicyclohexylphosphino) -3,6-dimethoxy-2',4',6'-triisopropylbiphenyl, BrettPhos ligand, 3,6-Dimethoxy-2',4',6'-triisopropyl-2- (dicyclohexylphosphino) biphenyl
HS Code
2931399090
Applications
1. Buchwald-Hartwig C-N Cross-Coupling: BrettPhos CAS 1070663-78-3 is the gold-standard ligand for palladium-catalyzed amination reactions. It achieves highly selective monoarylation of primary amines, effectively avoiding secondary diarylation by-products, and is widely used for synthesizing aromatic amine pharmaceutical intermediates. 2. Coupling Reaction of Inactive Aryl Chlorides: This ligand can activate low-reactivity aryl chlorides under mild reaction conditions, greatly reducing reaction temperature and catalyst dosage, solving the technical bottleneck of difficult coupling of cheap but inert aryl chloride substrates. 3. C-O and C-C Bond Formation Reactions: Applied in palladium-catalyzed etherification, Suzuki-Miyaura coupling and ketone alpha-arylation reactions, improving reaction yield and functional group compatibility for complex molecule synthesis. 4. Pharmaceutical API and Intermediate Mass Production: BrettPhos CAS 1070663-78-3 is suitable for large-scale industrial catalytic production of fine drugs, greatly simplifying synthetic routes and lowering overall production costs of chiral and aromatic drug molecules.
Purity
≥98% (HPLC)
Molecular Formula
C35H53O2P
Molecular Weight
536.78
Shelf Life
2 years under proper storage
Appearance
White to off-white crystalline powder
Grade
Catalyst Grade, Synthesis Grade, Ligand Grade
Density
No available public density data
Melting Point
126-130 °C
EINECS
Not available

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