3-Bromoisonicotinic acid

3-Bromoisonicotinic acid (CAS 13959-02-9) is a typical brominated pyridine carboxylic acid heterocyclic monomer, with a bromine substituent at the 3-position and a carboxyl group at the 4-position of the pyridine ring. This compound owns stable thermal performance, poor solubility in water and low-polarity solvents, and good solubility in strong polar organic solvents such as DMSO and methanol. It contains three active reaction sites including pyridine nitrogen atom, 3-position reactive bromine atom and 4-position carboxyl group, supporting esterification, amidation, nucleophilic substitution and multiple cross-coupling reactions. As a high-value halogenated pyridine building block, 3-Bromoisonicotinic acid (CAS 13959-02-9) is widely used in new drug development, custom organic synthesis and coordination material research.

3-Bromo-4-pyridinecarboxylic acid, 3-Bromopyridine-4-carboxylic acid, 4-Carboxy-3-bromopyridine, Isonicotinic acid, 3-bromo-

2933399990

1. Pharmaceutical Intermediate Synthesis: 3-Bromoisonicotinic acid (CAS 13959-02-9) is a key raw material for synthesizing anti-tuberculosis drugs, antibacterial small-molecule drugs and kinase inhibitors. The 3-bromo group can effectively adjust the lipophilicity and metabolic stability of drug molecules, while the terminal carboxyl group is convenient for molecular derivatization, helping accelerate lead compound screening and pharmaceutical process optimization. 2. Organic Cross-Coupling Reaction Building Block: The highly active bromine atom on pyridine ring makes this product suitable for Suzuki, Heck and Buchwald-Hartwig coupling reactions. Chemists can carry out directional structural modification at the 3-position to prepare a series of 3,4-disubstituted pyridine derivatives, which are core fragments for custom synthesis of complex heterocyclic compounds. 3. Coordination Chemistry Bifunctional Ligand: Equipped with pyridine nitrogen and carboxyl dual coordination sites, 3-Bromoisonicotinic acid (CAS 13959-02-9) can coordinate with various transition metal ions and rare earth ions. It is commonly used to prepare metal-organic framework materials, fluorescent coordination complexes and homogeneous catalysts for material chemistry research. 4. Agrochemical Intermediate Preparation: It serves as a precursor for synthesizing new fungicides and plant growth regulators. Pyridine derivatives prepared from this product feature high biological activity and low environmental residue, complying with the research and production direction of modern green agrochemicals.

≥98% (HPLC/GC)

C6H4BrNO2

202.01

2 years under proper storage

White to off-white crystalline solid

Pharmaceutical Intermediate Grade, Laboratory Reagent Grade, Organic Synthesis Grade

1.80±0.10 g/cm3 at 25 °C

237-238 °C

403.1±30.0 °C (Predicted)