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Methylisothiazolinone (Standard)

CAT: 0804-HY-W010520R-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W010520R-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methylisothiazolinone (Standard) is the analytical standard of Methylisothiazolinone. Methylothiazolinone is a fungicide and preservative, as well as a sensitizer. Methylisothiazolinone can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce cell apoptosis and inflammatory response. Methylisothiazolinone can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone can cause mitochondrial damage in the endothelium of rat cerebral blood vessels[1][2][4].
CAS Number
2682-20-4
UNSPSC
12352005
Hazard Statement
H314-H317-H330-H410
Target
Bacterial; MMP; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/methylisothiazolinone-standard.html
Smiles
CN1SC=CC1=O
Molecular Formula
C4H5NOS
Molecular Weight
115.15
Precautions
P260-P261-P264-P271-P272-P273-P280-P284-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P362+P364-P363-P391-P403+P233-P405-P501
References & Citations
[1]Park EJ, et al. Methylisothiazolinone induces apoptotic cell death via matrix metalloproteinase activation in human bronchial epithelial cells. Toxicol In Vitro. 2020 Feb;62:104661. |[2]Kim D, et al. Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat cerebrovascular endothelium. Toxicol Lett. 2022 Aug 1;366:45-57. |[3]Devos FC, et al. Methylisothiazolinone: dermal and respiratory immune responses in mice. Toxicol Lett. 2015 Jun 15;235 (3) :179-88. |[4]Go HN, et al. Effects of chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) on Th2/Th17-related immune modulation in an atopic dermatitis mouse model. Sci Rep. 2020 Mar 5;10 (1) :4099.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
No Development Reported

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