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Tenacissoside G

CAT: 0804-HY-N2103-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2103-01Size:5 mg
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Description
Tenacissoside G is a C21 steroid from the stems of Marsdenia tenacissima. Tenacissoside G reverses multidrug resistance in P-glycoprotein (Pgp) -overexpressing multidrug-resistant cancer cells[1][2].
CAS Number
191729-43-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P-glycoprotein
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tenacissoside-g.html
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]([C@@H]([C@@H](OC(/C(C)=C/C)=O)[C@]1([H])[C@]23C)OC(C)=O)([C@@H]4C(C)=O)[C@]5(CC4)[C@@]1(CC[C@@]2([H])C[C@@H](O[C@@](O[C@H](C)[C@H]6O[C@@](O[C@H](C)[C@@H](O)[C@H]7OC)([H])[C@@H]7O)([H])C[C@H]6OC)CC3)O5
Molecular Formula
C42H64O14
Molecular Weight
792.95
Precautions
H302, H315, H319, H335
References & Citations
[1]Lei YS, et al. [C21 steroids from the stems of Marsdenia tenacissima]. Yao Xue Xue Bao. 2008 May;43 (5) :509-12.|[2]Hu YJ, et al. Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells. J Nat Prod. 2008 Jun;71 (6) :1049-51.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

Tenacissimoside A

Tenacissoside G has been reported in Marsdenia tenacissima with data available.

CAS Number191729-43-8
PubChem CID44561398
IUPAC Name[(1S,3R,6R,7S,8S,9S,10S,11S,14S,16S)-6-acetyl-8-acetyloxy-14-[(2R,4R,5R,6R)-5-[(2S,3R,4R,5R,6R)-3,5-dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-7,11-dimethyl-2-oxapentacyclo[8.8.0.01,3.03,7.011,16]octadecan-9-yl] (E)-2-methylbut-2-enoate
Molecular FormulaC42H64O14
Molecular Weight792.9
XLogP3.1
Topological Polar Surface Area178
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count14
Rotatable Bond Count12
Heavy Atom Count56
Formal Charge0
Complexity1550
SMILES
C/C=C(\C)/C(=O)O[C@H]1[C@@H]2[C@]3(CC[C@@H](C[C@@H]3CC[C@@]24[C@@]5(O4)CC[C@H]([C@]5([C@@H]1OC(=O)C)C)C(=O)C)O[C@H]6C[C@H]([C@@H]([C@H](O6)C)O[C@H]7[C@@H]([C@@H]([C@@H]([C@H](O7)C)O)OC)O)OC)C
InChI
InChI=1S/C42H64O14/c1-11-20(2)37(47)54-34-35-39(7)15-13-26(53-29-19-28(48-9)32(23(5)50-29)55-38-31(46)33(49-10)30(45)22(4)51-38)18-25(39)12-16-41(35)42(56-41)17-14-27(21(3)43)40(42,8)36(34)52-24(6)44/h11,22-23,25-36,38,45-46H,12-19H2,1-10H3/b20-11+/t22-,23-,25+,26+,27+,28-,29+,30-,31-,32-,33-,34+,35-,36-,38+,39+,40+,41+,42-/m1/s1
InChIKey
OHDJGUWKOIBIKY-SGFNNURDSA-N
Chemical Structure
2D Structure
2D structure of Tenacissimoside A
CAS: 191729-43-8
CID: 44561398
Formula: C42H64O14
MW: 792.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight792.9
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count14
Rotatable Bond Count12
Exact Mass792.42960671
Monoisotopic Mass792.42960671
Topological Polar Surface Area178 Ų
Heavy Atom Count56
Formal Charge0
Complexity1550
Isotope Atom Count0
Defined Atom Stereocenter Count19
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-N13120-01Tenacissoside A
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HY-N13123Tenacissoside C
HY-N13125-01Tenacissoside E
HY-N2545Tenacissoside X
HY-N13124Tenacissoside D
HY-N1167Tenacissoside F
HY-N13122-01Tenacissoside B
HY-N0670-01Tenacissoside H
HY-N16577(S) -Tenacissoside F

Alternative Products

CatalogName
TN8089-01Tenacissoside A
TN8122-01Tenacissoside D
T6S1843-01Tenacissoside I
TN2369Tenacissoside X
TBW00462Tenacissoside F
BUP00084-01Tenacissoside H
N2128-20Tenacissoside G
TN8107-01Tenacissoside B
T89257-01Tenacissoside C

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