ZBT7A Polyclonal Antibody

• Background:

  Function:Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity) . Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'., similarity:Contains 1 BTB (POZ) domain., similarity:Contains 4 C2H2-type zinc fingers., subunit:Interacts with BCL6., tissue specificity:Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level) . In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level) . Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level) .

• Gene ID:

  51341

• Swiss Prot:

  O95365

• Cross Reactivity:

  Human; Mouse; Rat

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer:

  Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Molecular Weight:

  64

• Storage Conditions:

  -20°C/1 year

• Protein Weight:

  64