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TNKS1 Polyclonal Antibody

CAT: 1027-RA35406-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1027-RA35406-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catalytic activity:NAD (+) + (ADP-D-ribosyl) (n) -acceptor = nicotinamide + (ADP-D-ribosyl) (n+1) -acceptor., function:May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length., PTM:ADP-ribosylated (-auto) ., PTM:Phosphorylated on serine residues by MAPK kinases upon insulin stimulation., similarity:Contains 1 PARP catalytic domain., similarity:Contains 1 SAM (sterile alpha motif) domain., similarity:Contains 15 ANK repeats., subcellular location:Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1., subunit:Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2., tissue specificity:Ubiquitous; highest levels in testis.
Gene ID
8658
Swiss Prot
O95271
Cross Reactivity
Human; Mouse
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Molecular Weight
145
Storage Conditions
-20°C/1 year
Protein Weight
145

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