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SH21A Polyclonal Antibody

CAT: 1027-RA34830-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1027-RA34830-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SH2 domain containing 1A (SH2D1A) Homo sapiens This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been f
Gene ID
4068
Swiss Prot
O60880
Cross Reactivity
Human; Mouse; Rat
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Molecular Weight
14
Storage Conditions
-20°C/1 year
Protein Weight
14

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