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SARM1 Polyclonal Antibody

CAT: 1027-RA34730-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1027-RA34730-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caution:Was initially reported to contain ARM repeats (PubMed:11386760) . Such repeats are however not predicted by any detection method., function:Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation., similarity:Contains 1 TIR domain., similarity:Contains 2 SAM (sterile alpha motif) domains., subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function., tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.
Gene ID
23098
Swiss Prot
Q6SZW1
Cross Reactivity
Human; Mouse
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Molecular Weight
79
Storage Conditions
-20°C/1 year
Protein Weight
79

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