MIB2 Polyclonal Antibody

CAT: 1027-RA33313-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:1027-RA33313-01Size:50 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors., induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene., pathway:Protein modification; protein ubiquitination., PTM:Ubiquitinated. Possibly via autoubiquitination., similarity:Contains 1 ZZ-type zinc finger., similarity:Contains 2 MIB/HERC2 domains., similarity:Contains 2 RING-type zinc fingers., similarity:Contains 9 ANK repeats., subcellular location:Colocalizes with endosomal compartments., subunit:Interacts with actin monomer., tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
Gene ID
142678
Swiss Prot
Q96AX9
Cross Reactivity
Human; Mouse; Rat
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Molecular Weight
111
Storage Conditions
-20°C/1 year
Protein Weight
111

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