DTL Polyclonal Antibody

Developmental stage:Expressed in all fetal tissues examined, included brain, lung, liver, and kidney., function:Required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase. Seems to be necessary to ensure proper cell cycle regulation of DNA replication. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. May play a role in cell proliferation of NT2 embryonal carcinoma cells., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the WD repeat cdt2 family., similarity:Contains 7 WD repeats., subcellular location:Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis., subunit:Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF) . Interacts with CUL4B and DDB1., tissue specificity:Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.

51514

Q9NZJ0

Human; Mouse

Rabbit

WB; ELISA

WB 1:500-2000 ELISA 1:5000-20000

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

80

-20°C/1 year