DAB2 rabbit pAb

• Background :

  This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

• Product Name Alternative :

  Disabled homolog 2 (DOC-2) (Differentially-expressed protein 2)

• Gene ID :

  1601

• Swiss Prot :

  P98082

• Cross Reactivity :

  Human; Mouse; Rat

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB

• Dilution :

  WB 1:500-2000

• Buffer :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.333% sodium azide.

• Molecular Weight :

  85

• Storage Conditions :

  -20°C/1 year

• Protein Weight :

  85