CROCC Polyclonal Antibody

• Background :

  Function:Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis., PTM:Phosphorylated by NEK2 which may regulate its association with centrosomes. Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the rootletin family., subcellular location:In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase., subunit:Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250.

• Gene ID :

  9696

• Swiss Prot :

  Q5TZA2

• Cross Reactivity :

  Human; Rat; Mouse

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Molecular Weight :

  221

• Storage Conditions :

  -20°C/1 year

• Protein Weight :

  221