CDA7L Polyclonal Antibody

• Background :

  Function:Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1., induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line., miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation., subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction., subunit:Interacts with MYC and PSIP1., tissue specificity:Ubiquitous. Overexpressed in medulloblastoma.

• Gene ID :

  55536

• Swiss Prot :

  Q96GN5

• Cross Reactivity :

  Human; Rat; Mouse

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Molecular Weight :

  49

• Storage Conditions :

  -20°C/1 year

• Protein Weight :

  49