Stat2 (Acetyl Lys384) rabbit pAb

CAT: 1027-RA30100-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:1027-RA30100-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Function:Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state., PTM:Tyrosine phosphorylated in response to IFN-alpha., similarity:Belongs to the transcription factor STAT family., similarity:Contains 1 SH2 domain., subcellular location:Translocated into the nucleus upon activation by IFN-alpha/beta., subunit:Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein.

Product Name Alternative

Signal transducer and activator of transcription 2 (p113)

Gene ID

6773

Swiss Prot

P52630

Cross Reactivity

Human; Rat

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Dilution

WB 1:1000-2000 ELISA 1:5000-20000

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight

Storage Conditions

-20°C/1 year

Protein Weight

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Stat2 (Acetyl Lys384) rabbit pAb

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