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Sck Polyclonal Antibody

CAT: 1027-RA29678-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1027-RA29678-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Domain:The PID domain mediates binding to the TrkA receptor., function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons., miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576., PTM:Phosphorylated on tyrosines by the Trk receptors., similarity:Contains 1 PID domain., similarity:Contains 1 SH2 domain., subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2., tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.
Product Name Alternative
SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2
Gene ID
25759
Swiss Prot
P98077
Cross Reactivity
Human; Rat
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
59
Storage Conditions
-20°C/1 year
Protein Weight
59

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