PEN2 rabbit pAb

• Background :

  Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2) . Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

• Gene ID :

  55851

• Swiss Prot :

  Q9NZ42

• Cross Reactivity :

  Human; Mouse; Rat

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IHC-p; IF (paraffin section)

• Dilution :

  IHC-p 1: 50-200

• Buffer :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Storage Conditions :

  -20°C/1 year