PCSK9 rabbit pAb

• Background:

  Cofactor:Calcium., disease:Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant., enzyme regulation:Inhibited by EGTA., function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis., PTM:The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme., similarity:Belongs to the peptidase S8 family., similarity:Contains 1 peptidase S8 domain., subunit:The precursor protein but not the mature protein may form multimers., tissue specificity:Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

• Product Name Alternative:

  Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-; Neural apoptosis-regulated convertase 1; NARC-1; Proprotein convertase 9; PC9; Subtilisin/kexin-like protease PC9)

• Gene ID:

  255738

• Swiss Prot:

  Q8NBP7

• Cross Reactivity:

  Human; Rat; Mouse

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Dilution:

  WB 1:1000-2000 ELISA 1:5000-20000

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Storage Conditions:

  -20°C/1 year