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P53RFP Polyclonal Antibody

CAT: 1027-RA28418-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1027-RA28418-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caution:Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family., domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme., function:E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism., pathway:Protein modification; protein ubiquitination., PTM:Auto-ubiquitinated., similarity:Belongs to the RBR family. RNF144 subfamily., similarity:Contains 1 IBR-type zinc finger., similarity:Contains 2 RING-type zinc fingers., subunit:Interacts with UBE2L3, UBE2L6 and LCMT2., tissue specificity:Broadly expressed, with lowest levels in brain, spleen and thymus.
Product Name Alternative
RNF144B; IBRDC2; P53RFP; E3 ubiquitin-protein ligase RNF144B; IBR domain-containing protein 2; RING finger protein 144B; p53-inducible RING finger protein
Gene ID
255488
Swiss Prot
Q7Z419
Cross Reactivity
Human; Mouse
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
35
Storage Conditions
-20°C/1 year
Protein Weight
35

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