MLKL Polyclonal Antibody

• Background:

  Mixed lineage kinase domain like (MLKL) Homo sapiens This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]

• Product Name Alternative:

  MLKL; Mixed lineage kinase domain-like protein

• Gene ID:

  197259

• Swiss Prot:

  Q8NB16

• Cross Reactivity:

  Human; Rat; Mouse

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Dilution:

  Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Molecular Weight:

  55

• Storage Conditions:

  -20°C/1 year

• Protein Weight:

  55