MELK Polyclonal Antibody

• Background:

  Catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis., PTM:Autophosphorylated. Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily., similarity:Contains 1 KA1 (kinase-associated) domain., similarity:Contains 1 protein kinase domain., subunit:Interacts with ZNF622 and PPP1R8., tissue specificity:Expressed in placenta, kidney, thymus, testis, ovary and intestine.

• Product Name Alternative:

  MELK; KIAA0175; Maternal embryonic leucine zipper kinase; hMELK; Protein kinase Eg3; pEg3 kinase; Protein kinase PK38; hPK38; Tyrosine-protein kinase MELK

• Gene ID:

  9833

• Swiss Prot:

  Q14680

• Cross Reactivity:

  Human; Rat; Mouse

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IHC-p; IF/ICC; ELISA

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Molecular Weight:

  75

• Storage Conditions:

  -20°C/1 year

• Protein Weight:

  75