IDHP Polyclonal Antibody

• Background:

  Isocitrate dehydrogenase (NADP (+) ) 2, mitochondrial (IDH2) Homo sapiens Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP (+) -dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP (+) -dependent isozyme is a homodimer. The protein encoded by this gene is the NADP (+) -dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by Ref

• Product Name Alternative:

  Isocitrate dehydrogenase [NADP], mitochondrial (IDH; EC 1.1.1.42; ICD-M; IDP; NADP (+) -specific ICDH; Oxalosuccinate decarboxylase)

• Gene ID:

  3418

• Swiss Prot:

  P48735

• Cross Reactivity:

  Human; Mouse; Rat

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  IHC-p; IF (paraffin section) ; WB

• Dilution:

  IHC-p 1:50-200, WB 1:500-2000

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Molecular Weight:

  48

• Storage Conditions:

  -20°C/1 year

• Protein Weight:

  48