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ELL Polyclonal Antibody

CAT: 1027-RA24515-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1027-RA24515-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Disease:A chromosomal translocation involving ELL is found in acute leukemias. Translocation t (11;19) (q23; p13.1) with MLL/HRX. The result is a rogue activator protein., function:Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the ELL/occludin family., subcellular location:Colocalizes with EAF2 to nuclear speckles. Also localized to Cajal (coiled) bodies., subunit:Interacts with EAF1 and EAF2., tissue specificity:Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.
Product Name Alternative
ELL; C19orf17; RNA polymerase II elongation factor ELL; Eleven-nineteen lysine-rich leukemia protein
Gene ID
8178
Swiss Prot
P55199
Cross Reactivity
Human; Mouse
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC-p; IF (paraffin section) ; ELISA
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
65
Storage Conditions
-20°C/1 year
Protein Weight
65

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