CYFIP2 Polyclonal Antibody

• Background:

  Disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level) ., function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA., induction:By p53., RNA editing:Partially edited. Editing appears to be brain-specific., similarity:Belongs to the CYFIP family., subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus., subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.

• Product Name Alternative:

  Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)

• Gene ID:

  26999

• Swiss Prot:

  Q96F07

• Cross Reactivity:

  Human; Mouse; Rat

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Dilution:

  WB 1:500-2000, ELISA 1:10000-20000

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Molecular Weight:

  150+45

• Storage Conditions:

  -20°C/1 year

• Protein Weight:

  150+45