BMP4 rabbit pAb

• Background:

  Disease:Defects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6) [MIM:607932]; also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia) . In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS6 is characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies., function:Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair., online information:Bone morphogenetic protein 4 entry, similarity:Belongs to the TGF-beta family., subunit:Homodimer; disulfide-linked (By similarity) . Interacts with GREM2 (By similarity) and SOSTDC1. Part of a complex consisting of TWSG1 and CHRD., tissue specificity:Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.

• Product Name Alternative:

  Bone morphogenetic protein 4 (BMP-4; Bone morphogenetic protein 2B; BMP-2B)

• Gene ID:

  652

• Swiss Prot:

  P12644

• Cross Reactivity:

  Human; Rat; Mouse

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Dilution:

  WB 1:1000-2000 ELISA 1:5000-20000

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Storage Conditions:

  -20°C/1 year