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Isopteropodine

CAT: 0804-HY-N4157-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4157-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isopteropodine is a positive modulator that selectively acts on muscarinic M1 and 5-HT2 receptors. Isopteropodine has an EC50 of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research[1][2].
CAS Number
5171-37-9
UNSPSC
12352005
Hazard Statement
H300
Target
5-HT Receptor; Bacterial; mAChR
Type
Natural Products
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/isopteropodine.html
Purity
99.13
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CO[C@@H](C)[C@]([C@]1([H])C[C@]23[H])([H])CN2CC[C@]43C(NC5=C4C=CC=C5)=O)OC
Molecular Formula
C21H24N2O4
Molecular Weight
368.43
Precautions
H300
References & Citations
[1]Kang TH, et al. Pteropodine and isopteropodine positively modulate the function of rat muscarinic M (1) and 5-HT (2) receptors expressed in Xenopus oocyte. Eur J Pharmacol. 2002 May 24;444 (1-2) :39-45.|[2]García R, et al. Antimicrobial activity of isopteropodine. Z Naturforsch C J Biosci. 2005 May-Jun;60 (5-6) :385-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; mAChR1; α-1 microglobulin

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