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IAG933

CAT: 0804-HY-153811-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153811-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IAG933 (YAP-TEAD-IN-3) is an orally available YAP/TAZ-TEAD inhibitor that has anti-tumor effects and promotes apoptosis. IAG933 YAP-TEAD-IN-3 inhibits Avi-human TEAD4217-434, with an IC50 value of 9 nM[1][2].
CAS Number
2714434-21-4
Product Name Alternative
YAP-TEAD-IN-3
UNSPSC
12352005
Target
Apoptosis; YAP
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iag933-1.html
Purity
99.81
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
ClC(C(F)=CC1=C2C[C@](C3=CC=CC=C3)([C@@H]4CCCN4)O1)=[C@]2[C@@]5=C(C(NC)=O)C=NC(OCCO)=C5F
Molecular Formula
C27H26ClF2N3O4
Molecular Weight
529.96
References & Citations
[1]Bordas V, et al. Preparation of biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors. World Intellectual Property Organization, WO2021186324 A1. 2021-09-23.|[2]Emilie A Chapeau, et al. Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers. Nat Cancer. 2024 Jul;5 (7) :1102-1120.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
YAP/TAZ-TEAD

Alternative Products

CatalogName
C01702IAG933

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