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4-Methylesculetin

CAT: 0804-HY-N4288-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4288-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases[1][2].
CAS Number
529-84-0
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Cathepsin; Glutathione Peroxidase; Phosphatase
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/4-methylesculetin.html
Concentration
10mM
Purity
99.27
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C1C=C(C)C2=CC(O)=C(O)C=C2O1
Molecular Formula
C10H8O4
Molecular Weight
192.17
Precautions
H315, H319, H335
References & Citations
[1]Witaicenis A, et al. 4-methylesculetin, a coumarin derivative, ameliorates dextran sulfate sodium-induced intestinal inflammation. Chem Biol Interact. 2018 Jan 25;280:59-63.|[2]Hemshekhar M, et al. Antiarthritic and antiinflammatory propensity of 4-methylesculetin, a coumarin derivative. Biochimie. 2013 Jun;95 (6) :1326-35.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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