TLE1/2/3/4 Antibody

CAT: 1071-OM636797-01Size: 100 µLDry Ice: NoHazardous: No

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CAT#:1071-OM636797-01Size:100 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. PTM:Phosphorylated, probably by CDC2. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1. Belongs to the WD repeat Groucho/TLE family. Contains 6 WD repeats. subcellular location:Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components. subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif) . tissue specificity:In all tissues examined, mostly in brain, liver and muscle.

Immunogen

The antiserum was produced against synthesized peptide derived from the C-terminal region of human TLE1/TLE2/TLE3/TLE4. AA range:721-770

Antibody Type

Primary Antibodies

Product Name Synonym

Similar to transducin-like enhancer of split 1/2/3/4 antibody

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TLE1/2/3/4 Antibody

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