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SLP-76 Antibody

CAT: 1071-OM636510-01Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1071-OM636510-01Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T c
Immunogen
Synthesized peptide derived from SLP-76 . at AA range: 270-350
Antibody Type
Primary Antibodies
Product Name Synonym
LCP2 antibody; Lymphocyte cytosolic protein 2 antibody; SH2 domain-containing leukocyte protein of 76 kDa antibody; SLP-76 tyrosine phosphoprotein antibody; SLP76 antibody

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