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PML Antibody

CAT: 1071-OM635722-01Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1071-OM635722-01Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL) . Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
Immunogen
The antiserum was produced against synthesized peptide derived from human PML. AA range:11-60
Antibody Type
Primary Antibodies
Product Name Synonym
PML antibody; MYL antibody; RNF71 antibody; TRIM19 antibody; Protein PML antibody; Promyelocytic leukemia protein antibody; RING finger protein 71 antibody; Tripartite motif-containing protein 19 antibody

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