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P40-phox Antibody

CAT: 1071-OM635588-01Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1071-OM635588-01Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI (3) kinase, which suggests its role in PI (3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding d
Immunogen
The antiserum was produced against synthesized peptide derived from human p40 phox. AA range:120-169
Antibody Type
Primary Antibodies
Product Name Synonym
NCF4 antibody; SH3PXD4 antibody; Neutrophil cytosol factor 4 antibody; NCF-4 antibody; Neutrophil NADPH oxidase factor 4 antibody; SH3 and PX domain-containing protein 4 antibody; p40-phox antibody; p40phox antibody

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