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Valdecoxib-d3

CAT: 0804-HY-15762S-01Size: 2.5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15762S-01Size:2.5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Valdecoxib-d3 is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain[1][2].
CAS Number
1219794-90-7
Product Name Alternative
SC 65872-d3
UNSPSC
12352005
Hazard Statement
H361-H373
Target
COX; Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
NS(C(C=C1)=CC=C1C(C(C2=CC=CC=C2)=NO3)=C3C([2H])([2H])[2H])(=O)=O
Molecular Formula
C16H11D3N2O3S
Molecular Weight
317.38
Precautions
P260-P280-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Talley JJ, et al. 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. J Med Chem. 2000 Mar 9;43 (5) :775-7.|[3]Wiktorowska-Owczarek A. The effect of valdecoxib on the production of growth factors evoked by hypoxia and bacterial lipopolysaccharide in HMEC-1 cells. Adv Clin Exp Med. 2013 Nov-Dec;22 (6) :795-800.|[4]Kumar A, et al. Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress. Neurosci Bull. 2010 Feb;26 (1) :17-27.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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