Products for Research Use Only
RegisterLogin

Sabeluzole

CAT: 0804-HY-105022-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-105022-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease[1][2].
CAS Number
104383-17-7
Product Name Alternative
R 58735
UNSPSC
12352005
Target
Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sabeluzole.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C1CCN(CC(O)COC2=CC=C(F)C=C2)CC1)C3=NC4=C(C=CC=C4)S3
Molecular Formula
C22H26FN3O2S
Molecular Weight
415.52
References & Citations
[1]Hlinák Z, et al. Sabeluzole improves social recognition and antagonizes chlordiazepoxide's effect on habituation in the rat. Psychopharmacology (Berl) . 1991;104 (4) :505-9. |[2]Uberti D, et al. Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. Synapse. 1997 Jun;26 (2) :95-103.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
T28655-01Sabeluzole

Popular Products