Naftopidil

• Description:

  Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia[1][2].

• Product Name Alternative:

  KT-611; BM-15275

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/naftopidil.html

• Purity:

  98.47

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles:

  OC (CN1CCN (C (C=CC=C2) =C2OC) CC1) COC3=CC=CC4=CC=CC=C34

• Molecular Formula:

  C24H28N2O3

• Molecular Weight:

  392.49

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [2]R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79 (4) :447-54.|[1]Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila) . 2011 Jan;4 (1) :87-96.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  α adrenergic receptor

• CAS Number:

  57149-07-2