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Cdk5 Antibody

CAT: 498-bsm-70420MSize: 100 µLDry Ice: NoHazardous: No
100 µLSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cyclin-dependent kinases (Cdks) are a family of serine/threonine kinases that require association with regulatory subunits known as cyclins for activation. In addition, post-translational phosphorylation and dephosphorylation events regulate Cdk activity. Phosphorylation of Thr-160 in the T loop by Cdk-activating kinase (CAK) is an obligatory step in kinase activation. By contrast, phosphorylation of the Thr-14 and Tyr-15 residues by the Wee1 family of dual specificity kinases is inhibitory for the Cdks, and dephosphorylation of these residues by the Cdc25 family of phosphatases coincides with Cdk activation. Alternatively, Cdk5 appears to require different mechanisms for activation. This Cdk is activated through association with specific activators, including p35, p39, and p67. Cdk5 is primarily activated in neuronal cells, and only c-Abl kinase, rather than Wee family members, have been shown to phosphorylate Tyr-15 to regulate its activity.
Synonyms
PSSALRE, TPKII
Swiss Prot
Q00535
Host
Mouse
Cross Reactivity
Human, Mouse, Rat
Target
Cdk5
Clonality
Monoclonal
Isotype
IgG1
Clone
DC17+DC34
Conjugation
Unconjugated
Source
Clones DC17+DC34 were generated from a recombinant full-length human Cdk5 sequence.
Applications
WB, IP
Purification
Purified by Protein A.
Dilution
WB (1:300-5000), IP (1-2ug)
Buffer
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Modification
Unmodified
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Specificity
The antibody detects a 31 kDa* band corresponding to Cdk5 on SDS-PAGE immunoblots of human SYF and HeLa cells, and in mouse brain tissue. The antibody does not detect other Cdk family members, such as Cdk1 and Cdk2.

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