Syntaxin Antibody

• Background:

  Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007) . Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010) .

• Synonyms:

  HPC 1 antibody, Neuron specific antigen HPC1 antibody, Neuron-specific antigen HPC-1 antibody, OTTHUMP00000174615 antibody, OTTHUMP00000174616 antibody, OTTHUMP00000174617 antibody, OTTHUMP00000174618 antibody, P35-1 antibody, STX1 antibody, STX1A antibody, STX1A_HUMAN antibody, SYN1A antibody, Syntaxin 1A (brain) antibody, Syntaxin 1A brain antibody, Syntaxin-1A antibody

• Gene ID:

  6804

• Swiss Prot:

  Q16623

• Host:

  Mouse

• Cross Reactivity:

  Human, Rat, Pig, Hamster

• Target:

  Syntaxin

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Clone:

  SP8

• Conjugation:

  Unconjugated

• Source:

  Synaptic immunoprecipitate (crude) from human brain.

• Applications:

  WB, IHC

• Purification:

  Purified by Protein G.

• Concentration:

  Lot Dependent

• Dilution:

  WB (1:300-5000), IHC ()

• Buffer:

  10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

• Specificity:

  Specific for endogenous levels of the ~36 kDa syntaxin protein. The antibody has also been used for immunohistochemistry on formalin fixed, vibratome sections. *Does not work on paraffin sections.

• Gene ID URL:

  6804