16-Hydroxycleroda-3,13-dien-15,16-olide

• UNSPSC Description:

  16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy[1].

• Target Antigen:

  Dipeptidyl Peptidase

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/16-hydroxycleroda-3-13-dien-15-16-olide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(O1)C(CC[C@@]2([C@]3([H])[C@@](CC[C@H]2C)(C(C)=CCC3)C)C)=CC1=O

• Molecular Weight:

  318.45

• References & Citations:

  [1]Po-Kai Huang, et al. Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4. Int J Mol Sci. 2019 Jan 27;20(3):530.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  141979-19-3