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Flunarizine

CAT: 0804-HY-B0358-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0358-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Flunarizine is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects[1][2][3][4][5].
CAS Number
52468-60-7
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Calcium Channel; Dopamine Receptor; Sodium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/flunarizine.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C(N2CCN(C/C=C/C3=CC=CC=C3)CC2)C4=CC=C(F)C=C4)C=C1
Molecular Formula
C26H26F2N2
Molecular Weight
404.49
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Hong-Seob So, et al. Protective effect of T-type calcium channel blocker flunarizine on cisplatin-induced death of auditory cells. Hear Res. 2005 Jun;204 (1-2) :127-39.|[2]Qing Ye, et al. Flunarizine blocks voltage-gated Na (+) and Ca (2+) currents in cultured rat cortical neurons: A possible locus of action in the prevention of migraine. Neurosci Lett. 2011 Jan 10;487 (3) :394-9.|[3]Celia M Santi, et al. Differential inhibition of T-type calcium channels by neuroleptics. J Neurosci. 2002 Jan 15;22 (2) :396-403.|[4]Novalbos J, et al. Effects of dotarizine and flunarizine on chromaffin cell viability and cytosolic Ca2+. Eur J Pharmacol. 1999 Feb 5;366 (2-3) :309-17.|[5]Wan L, et al. Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury. Mediators Inflamm. 2020 Nov 10;2020:3691701.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
D2 Receptor
Citation 01
J Headache Pain. 2025 Jun 16;26 (1) :141.|bioRxiv. 2025 July 17.|J Ethnopharmacol. 2020 May 23;254:112727.|J Leukoc Biol. 2022 May;111 (5) :1021-1029.|Phytomedicine. 2025 Apr 11:142:156754.|Sci Rep. 2018 Nov 16;8 (1) :16932.

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