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Funapide

CAT: 0804-HY-16723-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16723-03Size:10 mg
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Description
Funapide (TV 45070; XEN402) is an orally active inhibitor of voltage-gated sodium channels (VGSC) in the peripheral nervous system with IC50 values ??of 84 nM and 54 nM for Nav1.5 and Nav1.7, respectively. Funapide has analgesic effects[1][2].
CAS Number
1259933-16-8
Product Name Alternative
TV 45070; XEN402
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Funapide.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C([C@]12COC3=C1C=C(OCO4)C4=C3)N(CC5=CC=C(C(F)(F)F)O5)C6=C2C=CC=C6
Molecular Formula
C22H14F3NO5
Molecular Weight
429.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Kitano Y, et al. Inhibition of NaV1.7: the possibility of ideal analgesics. RSC Med Chem. 2022 Aug 1;13 (8) :895-920.|[2]Price N , et al. Safety and Efficacy of a Topical Sodium Channel Inhibitor (TV-45070) in Patients With Postherpetic Neuralgia (PHN) : A Randomized, Controlled, Proof-of-Concept, Crossover Study, With a Subgroup Analysis of the Nav1.7 R1150W Genotype. Clin J Pain. 2017 Apr;33 (4) :310-318.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Nav1.2; Nav1.5; Nav1.6; Nav1.7; Nav1.8

Chemical Information

Funapide

Funapide has been used in trials studying the treatment of Pharmacokinetics, Postherpetic Neuralgia, and Osteoarthritis of the Knee.

CAS Number1259933-16-8
PubChem CID49836093
IUPAC Name(7S)-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one
Molecular FormulaC22H14F3NO5
Molecular Weight429.3
XLogP3.5
Topological Polar Surface Area61.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count2
Heavy Atom Count31
Formal Charge0
Complexity734
SMILES
C1[C@]2(C3=CC=CC=C3N(C2=O)CC4=CC=C(O4)C(F)(F)F)C5=CC6=C(C=C5O1)OCO6
InChI
InChI=1S/C22H14F3NO5/c23-22(24,25)19-6-5-12(31-19)9-26-15-4-2-1-3-13(15)21(20(26)27)10-28-16-8-18-17(7-14(16)21)29-11-30-18/h1-8H,9-11H2/t21-/m0/s1
InChIKey
NEBUOXBYNAHKFV-NRFANRHFSA-N
Chemical Structure
2D Structure
2D structure of Funapide
CAS: 1259933-16-8
CID: 49836093
Formula: C22H14F3NO5
MW: 429.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight429.3
XLogP33.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count2
Exact Mass429.08240703
Monoisotopic Mass429.08240703
Topological Polar Surface Area61.1 Ų
Heavy Atom Count31
Formal Charge0
Complexity734
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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