MARCH3 Polyclonal Antibody

• Background :

  Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s) . MARCH3 (membrane-associated ring finger (C3HC4) 3), also known as RNF173, is a 253 amino acid multi-pass membrane protein that localizes to cytoplasmic vesicles and early endosomes and contains one RING-CH-type zinc finger. Involved in the pathway of protein modification, MARCH3 functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to be involved in endosomal trafficking events.

• Synonyms :

  E3 ubiquitin-protein ligase MARCH3; FLJ20096; MARCH-III; March3; MARH3_HUMAN; Membrane associated ring finger C3HC4 3; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; RING finger protein 173; RNF173.

• Gene ID :

  115123

• Host :

  Rabbit

• Cross Reactivity :

  Mouse

• Immunogen :

  101-200/253

• Target :

  MARCH3

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Conjugation :

  Unconjugated

• Source :

  KLH conjugated synthetic peptide derived from human MARCH3

• Applications :

  WB, IHC-P, IF (IHC-P)

• Purification :

  Purified by Protein A.

• Concentration :

  1µg/µl

• Dilution :

  WB (1:300-5000), IHC-P (1:200-400), IF (IHC-P) (1:50-200)

• Buffer :

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification :

  Unmodified

• Storage Conditions :

  Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

• Gene ID URL :

  115123

• Predicted Cross Reactivity :

  Human, Rat, Cow, Sheep, Pig, Horse, Chicken, Rabbit