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RNF142 Polyclonal Antibody

CAT: 0498-bs-9156RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-9156RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SH3MD2 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) . SH3MD2 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane. This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. There are two named isoforms.
Synonyms
Plenty of SH3 domains; Plenty of SH3s; POSH; Ring finger protein 142; RNF 142; RNF142; SH3 domain containing ring finger 1; SH3 domain containing RING finger protein 1; SH3MD2; SH3 multiple domains 2; SH3RF1.
Gene ID
57630
Host
Rabbit
Cross Reactivity
Rat
Immunogen
401-500/888
Target
RNF142
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human SH3MD2/RNF142
Applications
WB, IHC-P, IF (IHC-P)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (IHC-P) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
57630
Predicted Cross Reactivity
Human, Mouse, Dog, Cow, Sheep, Horse, Chicken, Rabbit

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