TRIM50 Polyclonal Antibody

CAT: 0498-bs-9152RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-9152RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM50 (tripartite motif containing 50), also known as TRIM50A or E3 ubiquitin-protein ligase TRIM50, is a 487 amino acid cytoplasmic protein that functions as an E3 ubiquitin-protein ligase. Containing one RING-type zinc finger, a B30.2/SPRY domain and a single B box-type zinc finger, TRIM50 belongs to the TRIM/RBCC family and undergoes post-translational auto-ubiquitination. TRIM50 exists as two alternatively spliced isoforms, designated TRIM50 alpha and TRIM50 beta, and has the ability to form dimers and trimers. The gene encoding TRIM50 maps to human chromosome 7, which houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
Synonyms
E3 ubiquitin ligase; E3 ubiquitin protein ligase TRIM50; TRIM50A; Tripartite mot containing protein 50; tripartite mot protein 50A; tripartite mot-containing 50A; TRI50_HUMAN.
Gene ID
135892
Host
Rabbit
Immunogen
301-400/487
Target
TRIM50
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human TRIM50
Applications
WB, IHC-P, IF (IHC-P)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (IHC-P) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
135892
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Pig, Horse

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