CINP Polyclonal Antibody, Cy5 Conjugated

• Background:

  Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks) . Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Specifically, Cdk2 interacts with Cyclins A, B1, B3, D, or E to control cell cycle progression. The Cyclin-dependent kinase 2-interacting protein (CINP) interacts with components of the replication complex and Cdk2 and Cdc7, thereby providing a functional and physical link between Cdk2 and Cdc7 during firing of the origins of replication. However, CINP is phopshorylated by Cdc7, but not by Cdk2. CINP also interacts with ATR-interacting protein and regulates ATR-dependent signaling, resistance to replication stress and G2 checkpoint integrity.

• Synonyms:

  CINP protein; CDK2-interacting protein; CINP; CINP_HUMAN; Cyclin dependent kinase 2 interacting protein; Cyclin-dependent kinase 2-interacting protein; MGC849.

• Gene ID:

  51550

• Host:

  Rabbit

• Cross Reactivity:

  Human, Mouse, Rat

• Immunogen:

  51-150/212

• Target:

  CINP

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Cy5

• Source:

  KLH conjugated synthetic peptide derived from human CINP

• Applications:

  WB, IF (IHC-P)

• Purification:

  Purified by Protein A.

• Excitation Emission:

  625,650nm/670nm

• Concentration:

  1µg/µl

• Dilution:

  WB (1:300-5000), IF (IHC-P) (1:50-200)

• Buffer:

  Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

• Gene ID URL:

  51550