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CLEC 4E Polyclonal Antibody, Biotin Conjugated

CAT: 0498-bs-8541R-Biotin-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-8541R-Biotin-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
Synonyms
C type lectin domain family 4 member E; C type lectin superfamily member 9; C-type calcium dependent carbohydrate recognition domain lectin superfamily member 9; C-type lectin domain family 4 member E; C-type lectin superfamily member 9; CLC4E_HUMAN; CLEC 4E; CLEC4E Clec4e; CLECSF9; Macrophage inducible C type lectin; Macrophage-inducible C-type lectin; MINCLE.
Gene ID
26253
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
51-150/219
Target
CLEC 4E
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from human CLECSF9/CLEC4E
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
26253
Predicted Cross Reactivity
Mouse, Rat, Cow, Horse

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