RPS3 Polyclonal Antibody

CAT: 0498-bs-7571RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-7571RSize:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699) . Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413) . Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971) . Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345) . Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840) . Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571) . Enhances the uracil excision activity of UNG1 (PubMed:18973764) . Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764) . When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537) . Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931) . Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535) . Represses its own translation by binding to its cognate mRNA (PubMed:20217897) . Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744) . Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551) . Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002) . Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787) . Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408) .
Synonyms
S3; 40S ribosomal protein S3; RPS3; OK/SW-cl.26
Gene ID
6188
Swiss Prot
P23396
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human, Mouse
Immunogen
101-200/243
Target
RPS3
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human RPS3
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
6188
Predicted Cross Reactivity
Rat, Zebrafish, Non-Human Primate, Xenopuslaevis

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