NOTCH4 Polyclonal Antibody

• Background:

  Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.

• Synonyms:

  Notch 4; FLJ16302; hNotch 4; hNotch4; INT 3; INT3; MGC74442; Neurogenic locus notch homolog protein 4; NOTC4_HUMAN; NOTCH 3; NOTCH 4; Notch 4 intracellular domain; Notch homolog 4; NOTCH3; Notch4; NOTCH4 protein; OTTHUMP00000062678.

• Gene ID:

  4855

• Swiss Prot:

  Q99466

• Cellular Locus:

  Nucleus, Cell membrane

• Host:

  Rabbit

• Cross Reactivity:

  Human, Mouse, Rat

• Immunogen:

  1151-1250/2003

• Target:

  NOTCH4

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Source:

  KLH conjugated synthetic peptide derived from human NOTCH4

• Applications:

  ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification:

  Purified by Protein A.

• Concentration:

  1µg/µl

• Dilution:

  ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

• Gene ID URL:

  4855

• Predicted Cross Reactivity:

  Dog, Cow, Sheep, Pig, Horse, Rabbit